Mac Fonts

It is a good idea to remove all the fonts from ~/Library/Fonts and /Library/Fonts but leave /System/Library/Fonts alone.

Create a "My Fonts" folder, dump your fonts in there and activate when necessary.

Here are two good overviews of how the OSes handle fonts:

Leopard:  http://www.prepressure.com/fonts/basics/leopard_fonts

Snow Leopard:  http://www.prepressure.com/fonts/basics/snow-leopard-fonts